Histidine What is it? (physiology and clinical effects) Histidine is an amino acid, essential for growth and repair of tissues. It helps protect nerve cells, and is needed for the production of red and white blood cells. Histidine is the precursor to histamine, which is a substance released during an allergic reaction. Low levels of histidine may be a causal factor to rheumatoid arthritis. Clinically relevant conditions: Rheumatoid arthritis Food Sources: Rice, wheat, rye, seafood, turkey, chicken, pork, beef, eggs, beans Risk factors and symptoms of deficiency: (who is likely deficient) None Recommended dosage: (how much usually taken) 250-500 mg three times daily between meals. Contraindications:(side effects / precautions / interactions / drug interactions) High histidine levels may lead to stress and psychological disorders such as anxiety and schizophrenia. Individuals with bipolar depression and schizophrenia should avoid supplementation. Also individuals with severe allergies and migraines should use histidine with caution, as they may exacerbate their condition. Histidine is best taken with vitamins B3 and vitamine B6, which help its conversion to histamine. Copyright © 2006 R & G Global Holding LLC All rights reserved. www.myNDonline.com The information provided on myNDonline is not intended to replace or be used in place of medical advice given by a licensed healthcare professional.