Folic Acid - (Folate) What is it? (physiology and clinical effects) Folate is very important during pregnancy for embryonic and fetal nerve cell formation. It is necessary to prevent neural tube defects, such as spina bifida and is therefore must be taken early in pregnancy. Folate along with vitamin B6 and B12 have been shown to reduce homocysteine levels. High homocysteine levels have been linked to increased risk of atherosclerosis and heart disease. Folate is also needed for energy production, formation of red blood cells, and proper functioning of the immune system. Clinically relevant conditions: Alcoholism Autism Bipolar disorder Canker sores Cervical dysplasia Cleft lip / cleft palate Coronary heart disease Depression Diabetic neuropathy Glossitis Gout Megaloblastic anemia Neuralgia / neurtitis Periodontal disease Psoriasis Restless leg syndrome Seizures Stroke (prevention) Ulcerative colitis Vertigo Food Sources: Dark green leafy vegetables (spinach, kale, broccoli), organ meats, brewer's yeast, kidney beans, beets, lima beans, whole grains Risk factors and symptoms of deficiency: (who is likely deficient) Macrocytic anemia, sore and red tongue, apathy, fatigue, graying hair, digestive upset, palpitations, memory problems, shortness of breath, weakness, growth impairment. Recommended dosage: (how much usually taken) 400-800 micrograms daily Contraindications:(side effects / precautions / interactions / drug interactions) Generally safe. High doses may interfere with effect of anticonvulsants and may increase frequency of seizures. Supplementation may mask laboratory diagnosis of pernicious anemia and B12 deficiency Copyright © 2006 R & G Global Holding LLC All rights reserved. www.myNDonline.com The information provided on myNDonline is not intended to replace or be used in place of medical advice given by a licensed healthcare professional.