DHEA What is it? (physiology and clinical effects) DHEA is a steroid hormone produced by the adrenal gland. It is the precursor to other hormones, including testosterone, progesterone, and corticosterone. DHEA is responsible in supporting the body to deal with stress, aids in immune function, inflammation, enhancing libido, cognitive function, and metabolism. Epidemiologic studies show a correlation between high levels of DHEA and longevity. Since, the levels of DHEA in the body decline with age, supplementation may help to enhance immune and cognitive function, and to prevent cancer, heart disease, multiple sclerosis, Alzheimer's disease, and may reduce the severity of several autoimmune conditions. Clinically relevant conditions: Aging (prevention) Alzheimer's disease Arthritis Chronic fatigue syndrome / Fatigue / fibromyalgia Heart disease prevention Immune support Low blood levels of DHEA Lupus Menopause Osteoporosis Poor concentration / memory Ulcerative colitis Prednisone withdrawal Food Sources: None known Risk factors and symptoms of deficiency: (who is likely deficient) None known. However since DHEA levels decline with age supplementation may be recommended. Recommended dosage: (how much usually taken) Consult with your healthcare practitioner. Start at dose of 5-15 mg daily and increase according to your clinical condition. Contraindications:(side effects / precautions / interactions / drug interactions) Avoid if you are pregnant or breast feeding or have an existing cancer. Woman at high risk of breast cancer, and men at high risk of prostate cancer, should start at low doses. Signs of overdose include acne, male-pattern hair growth (hirtuism) in woman, and breast tenderness. Individuals with acne, high testosterone levels, ovarian cancer, or high blood DHEA levels avoid supplementation. DHEA may cause thyrotoxicosis (severe heart palpitions) in individuals taking thyroid medication. High doses of supplemental DHEA may suppress the body's natural ability to make this hormone, and may lead to liver damage. It is recommended to also take antioxidant supplements such as vitamin C and E and antioxidant mineral selenium to prevent the oxidative damage to the liver. Copyright © 2006 R & G Global Holding LLC All rights reserved. www.myNDonline.com The information provided on myNDonline is not intended to replace or be used in place of medical advice given by a licensed healthcare professional.